On Mar 21, 8:45*am, "chorley...@gmail.com" <chorley...@gmail.com>
wrote:
I suggest you seek treatment.
<<
I suggest you grow some balls ..
That ain't gonna happen ..
Heh .. heh ..
I suppose this would be to offset the high hemoglobin found in those
with
diabetes ..
Dexamethasone Implants Improve Diabetic Macular Edema
http://www.medscape.com/viewarticle/718820
NEW YORK (Reuters Health) Mar 18 - An intravitreal dexamethasone
delivery system improves diabetic macular edema, researchers report
in
the March issue of Archives of Ophthalmology.
The intravitreal implant (Ozurdex, Allergan) contains dexamethasone
in
a solid polymer drug delivery system. Literature from its
manufacturer
says that in earlier clinical trials, 20% to 30% of patients had at
least a 15-letter (3 lines) improvement in best-corrected visual
acuity within two months after implantation, with improvements
lasting
"approximately one to three months after onset of this effect."
In the current study, Dr. Julia A. Haller of the Wills Eye Institute,
Philadelphia, and colleagues focused on 171 clinical trial subjects
with persistent diabetic macular edema (one eye in each person). The
phase II trial had three arms: a 250 ug dexamethasone implant, a 700
ug system, or observation only.
At 90 days, 33.3% of the 700 ug group, 21.1% of the 250 ug group, and
12.3% of controls had improvements of at least 10 letters in their
best-corrected visual acuity.
The difference between the higher dose implant and observation was
statistically significant at days 60 and 90. At 180 days, the visual
acuity improvement persisted in 30% of the 700 ug group, 19% of the
350 ug group, and 23% of the observation group; at this point, the
differences were no longer significant.
Both treatment groups had significant improvements in central retinal
thickness and fluorescein leakage compared with the observation
group.
The implants were well tolerated, Dr. Haller told Reuters Health by
email, and they appear "to be a promising new treatment option for
eyes with persistent diabetic macular edema."
The trial was sponsored by Oculex Pharmaceuticals (developer of the
Ozurdex system) and Allergan, the parent company of Oculex.
Arch Ophthalmol 2010;128:289-296.
------------------
-------------
"Inhibitory effect of dexamethasone on in vivo erythropoiesis"
"Erythropoietic depression was elicited by cyclophosphamide
administration"
It's curious how these VERY popular drugs .. reduce blood cell count.
Reduce the number of red blood cells.
Somewhat like .. bloodletting.
Enhanced hypoxia-stimulated erythropoietin production in mice with
depression of erythropoiesis induced by hyperoxia.
High Alt Med Biol. 2003 Spring;4(1):73-9.
Bozzini CE, Barceló AC, Conti MI, Martínez MP, Alippi RM.
Department of Physiology, Faculty of Odontology, University of Buenos
Aires, Argentina. ceb...@fisio.odon.uba.ar
Current evidence suggests that a modulatory action on O(2)-dependent
EPO secretion is exerted by the erythroid/precursor cell population
in
the erythropoietic organs through a negative feedback system.
The hypothesis is based on studies of stimulated-EPO secretion
performed in mice in whom the erythropoietic rates were either
enhanced or depressed in the presence of normal plasma EPO half-
lives.
Since erythropoietic depression was elicited by cyclophosphamide
administration, which could have altered EPO production directly, the
aim of the present investigation was to estimate hypoxia-stimulated
EPO secretion in a mouse model of functional depressed erythropoiesis
induced by exposure to normobaric hyperoxia.
Females CF#1 mice aged 70 d were divided into control (C) and
experimental (E) groups.
The former was maintained in plastic cages in a normal environment,
while the latter was placed in an environment of 60% O(2)/40% N(2) in
an 85-dm(3) atmospheric chamber with air flow of 1 L/min.
Erythropoiesis was evaluated by either 24-h RBC-(59)Fe uptake or iron
kinetics performed 3 h after IV injection of a tracer dose of (59)Fe.
Both indexes of the red cell production rate were significantly
depressed in E mice. Plasma disappearance of exogenous EPO in C mice,
as well as in E mice exposed to hyperoxia for 4 d, was estimated by
injecting (125)I-rHuEPO intravenously.
Linear regression analysis indicated that neither the differences
between the slopes of both curves nor the Y-intercepts were
significant.
Hypobaric hypoxemia was used as stimulus for EPO production.
Plasma immuno-EPO titer after a 4-h exposure to hypobaric air was 73%
higher in mice with hyperoxia-induced hypoerythropoiesis than in
control mice with normal erythropoiesis.
Data support the concept that the rate of erythropoiesis, perhaps
through the number of the erythroid progenitor/precursor cell
population, modulates O(2)-dependent EPO secretion.
PMID: 12713714
-------------------
Exp Hematol. 1980 Aug ;8 (7):911-6 16398023 (P,S,G,E,B) Mechanism
underlying the inhibitory effect of dexamethasone on in vivo
erythropoiesis.
[My paper] M J Giglio, R M Alippi, C E Bozzini
Cátedras de Fisiología, Facultad de Odontología, Universidad de
Buenos
Aires, República Argentina.
The time-response curve for RBC-59Fe uptake following i.p. injection
of 5 mg of dexamethasone into normal, non-polycythemic mice, shows a
maximal depression (50% of normal) at 3 days after dexamethasone with
return to almost normal values by 5 days. The effect is dose-related
showing a plateau with doses of dexamethasone above 3 mg. The shape
of
the time-response curve indicates that the more mature cells in the
erythron are not affected by dexamethasone and that the major effect
of the steroid must be on earlier erythroid cells. Intravenous
injection of dexamethasone 33 and 48 h after i.v. injection of
erythropoietin in post-hypoxic polycythemic mice has no effect on the
response to erythropoietin, suggesting that the early and late
erythroblasts develop normally into erythrocytes. Injection of
dexamethasone 13 h after erythropoietin is also ineffective,
suggesting that the final steps of differentiation from
erythropoietin
responsive cells (ERC) to proerythroblasts are not affected. On the
contrary, injection of dexamethasone 1 h after erythropoietin reduces
by 60% the effective erythropoiesis, which can be attributed to a
decrease in differentiation of ERC into proerythroblasts. These
results indicate that the inhibitory action of dexamethasone on
erythropoiesis is exerted on cells of the erythroid line before the
stage of proerythroblast is reached.
Mesh-terms: Animals; Anti-Inflammatory Agents :: administration &
dosage; Cell Differentiation :: drug effects; Cells, Cultured;
Colony-
Forming Units Assay; Dexamethasone :: administration & dosage; Dose-
Response Relationship, Drug; Erythroblasts :: cytology;
Erythroblasts :: physiology; Erythropoiesis :: drug effects;
Erythropoietin :: administration & dosage; Female; Mice; Research
Support, Non-U.S. Gov't;
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk
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