I suppose there is much interpretation as to what would be meant by
"large scale". No, there have not been many studies involving
thousands of patients. Also, there have not been many studies that
compare results of ten years ago to results of today, but one can look
at ten year old studies and compare them with studies of today. In
fact, you can just go over to the FDA's website and look at the
outcomes for the laser approvals to see that outcomes have most
certainly improved.
Infrared pupil size measurement is one evaluation that was not done
way back when, but wavefront diagnosis didn't exist in 1997. Few
doctors actually did TBU and Shirmer tests then, many do now.
Pachemetry has improved. The Orbscan II now provides a better
diagnostic tool for keratoconus.
Keep in mind, in 1997 doctors were still discussing if a 5.0mm optical
ablation zone without transition really needed to be larger and if a
transition zone was necessary.
Glenn Hagele
Executive Director
USAEyes.org
"Consider and Choose With Confidence"
Email to glenn dot hagele at usaeyes dot org
http://www.USAEyes.org
http://www.ComplicatedEyes.org
I am not a doctor.