(2008) Study of the eye and lacrimal glands in experimental iron
overload in rats in vivo
Anatomical Science International 83 (1) , 11–16
Maria Repanti, Sotiris P. Gartaganis, Nikoleta M. Nikolakopoulou,
Aikaterini Ellina, Dimitris A. Papanastasiou Abstract
Original Article
Study of the eye and lacrimal glands in experimental iron overload in
rats in vivo
Maria Repanti 11 Institute of Pathology, St Andreas General Hospital
of Patras and Departments of , Sotiris P. Gartaganis 22 Ophthalmology
and , Nikoleta M. Nikolakopoulou 33 Pediatrics, School of Medicine,
University of Patras, Patras, Greece, Aikaterini Ellina 33 Pediatrics,
School of Medicine, University of Patras, Patras, Greece and Dimitris
A. Papanastasiou 33 Pediatrics, School of Medicine, University of
Patras, Patras, Greece1 Institute of Pathology, St Andreas General
Hospital of Patras and Departments of 2 Ophthalmology and 3
Pediatrics, School of Medicine, University of Patras, Patras, Greece
Correspondence: Dimitris A. Papanastasiou, Department of Pediatrics,
School of Medicine, University of Patras, 265 00 Patras, Greece.
Email:
(E-Mail Removed)
Key words: eye, hemosiderosis, lacrimal glands, transferrin.
Abstract
A variety of syndromes leading to hemosiderosis in men cause ocular
lesions.
The purpose of the present study was to determine the distribution of
iron and of transferrin in the eyes and lacrimal glands of rats in
experimental hemosiderosis, so as to achieve a better understanding of
the formation of the ocular lesions observed in patients with advanced
hemosiderosis.
In order to achieve hemosiderosis the rats were fed 3% (w/w) carbonyl
iron or received i.p. or i.v. polymaltose iron.
Hemosiderin deposits were detected in macrophages lying in the
interlobular connective tissue of lacrimal glands, in the interstitial
connective tissue of the choroid, in the ciliary body, in the iris and
extracellularly in the sclera in all animals that received iron i.v.
Also, scanty hemosiderin laden macrophages were found to a lesser
degree in interstitial connective tissue of the choroid and in the
interlobular connective tissue of lacrimal glands in animals that
received iron i.p.
No iron deposits were detected in the eye and lacrimal glands of
control rats and in rats that were on an iron enriched diet.
No transferrin was detected in the eye and in the lacrimal glands,
neither in the control rats nor in the rats that received iron.
Experimental iron overload leads to increased iron deposition in
tissues of the eye and lacrimal glands, whereas no transferrin could
be detected in the aforementioned organs.
doi:10.1111/j.1447-073X.2007.00195.x
Anatomical Science International
Volume 83 Issue 1 Page 11-16, March 2008
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