Iron levels in human retina: sex difference and increase with age.
Hahn P, Ying GS, Beard J, Dunaief JL
Neuroreport. 2006 Nov 27; 17(17): 1803-1806
Oxidative stress is believed to be important in physiological aging and
age-related diseases. Iron is a potent pro-oxidant implicated in
several age-related diseases. While serum ferritin, as an estimate of
body stores of iron, has been shown to increase with age, few studies
have directly addressed the effect of age on human neural tissue iron
levels. We used atomic absorption spectrophotometry to assess
quantitatively iron levels within the eye structures, retina and
retinal pigment epithelium/choroid of normal human eyes of various ages
and of both sexes. We found that retinal iron increases with age,
similar to serum ferritin levels. Women had more retinal iron than men
at all ages, suggesting that there may be gender-specific influences on
iron regulation.
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Terms Related · Graph Tag · Scopus · Cites
10.1097/WNR.0b013e3280107776
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