Lipofuscin Reversal

Molecular medicine in ophthalmic care.
Richer S, Stiles W, Thomas C
Optometry 2009 Dec; 80(12):695-701.

BACKGROUND:
Lipofuscin is the most consistent and phylogenically
constant morphologic marker of cellular aging.
Autofluorescence of the A2E fluorophore within
retinal pigment epithelial (RPE) lipofuscin affords
the opportunity for noninvasive evaluation of age-
and disease-related pathophysiological changes in the
human retina.
It is being used in National Eye Institute/Age-Related
Eye Disease Study II to evaluate age-related macular
degeneration (AMD) geographic atrophy expansion.
Experiments show lipofuscin can be reversed in cell
culture and animal models in heart, brain, spinal cord,
and retinal tissues, using an array of antioxidants
and iron chelators.
METHODS:
An 80-year-old man with a gastric resection presented
with complaints of unremitting night driving difficulty
despite treatment with lutein and omega III fatty acids.
Notable parafoveal deposition of retinal lipofuscin by
50 degrees fundus auto-fluorescence
(580 nm excitation/660 barrier filters) and concurrent
abnormalities in non-Snellen measures of visual
function-Contrast Sensitivity Function, 6.5 degrees
large field tritan threshold, 10 degrees threshold visual
fields, and deficits in the National Institutes of
Health/National Eye Institute Visual Function Questionnaire
(VFQ) 25 subjective night driving/mental health subscale
questionnaire were obtained.
The patient was placed on an over-the-counter daily oral
polyphenolic mixture containing resveratrol and re-evaluated
5 months later.
RESULTS: The data reveal improvements in all measures of
visual function, subjective improvement in vision and mental
functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
CONCLUSION:
To our knowledge, we believe this to be the first reported human
clinical case of lipofuscin reversal in the human eye correlated
with measured clinical and subjective improvement in visual and
mental function after nutraceutical intervention.


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

"The patient was placed on an over-the-counter daily oral
polyphenolic mixture containing resveratrol and re-evaluated
5 months later.
RESULTS: The data reveal improvements in all measures of
visual function, subjective improvement in vision and mental
functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
CONCLUSION:
To our knowledge, we believe this to be the first reported human
clinical case of lipofuscin reversal in the human eye correlated
with measured clinical and subjective improvement in visual and
mental function after nutraceutical intervention."

Problem is the otc drug is not a "nutraceutical intervention", it is a
drug intervention because that substance is not found in foods at those
pharmacological levels.

An aspirin like substance can be found in willow bark. If one chews it
for pain relief is it a "nutraceutical intervention"?

On Nov 27, 6:07*am, co...@lover.com wrote: Problem is the otc drug is
not a "nutraceutical intervention", it is a drug intervention
because that substance is not found in foods at those
pharmacological levels. <<

IF the resveratrol and polyphenol mixture is good at what it does then
one could almost consider it to be an iron chelator mixture ..

Therefore an .. iron reduction therapy ..

Iron reduction therapy ..

Can Lipofuscin Accumulation Be Prevented?
Rejuvenation Res 2007 Dec 26.
Kurz T

During normal autophagic degradation of mitochondria and iron-
containing proteins in lysosomes, iron is released intralysosomally
where it may react with hydrogen peroxide forming hydroxyl radicals
(Fenton reaction). Depending on their rate of formation, these highly
reactive radicals can cross-link intralysosomal material, leading to
lipofuscin formation, or destabilize the lysosomal membrane, which
induces apoptosis/necrosis. Since the sensitivity of lysosomes to
oxidative stress can be manipulated by altering the intralysosomal
level of redox-active iron, it follows that lipofuscin formation might
also be influenced. It is suggested that pulse doses of iron chelators
that easily penetrate membranes could be used to diminish
lipofuscinogenesis.

More from this journal
Rejuvenation Res


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> "The patient was placed on an over-the-counter daily oral
> polyphenolic mixture containing resveratrol and re-evaluated
> 5 months later.
> RESULTS: The data reveal improvements in all measures of
> visual function, subjective improvement in vision and mental
> functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
> CONCLUSION:
> To our knowledge, we believe this to be the first reported human
> clinical case of lipofuscin reversal in the human eye correlated
> with measured clinical and subjective improvement in visual and
> mental function after nutraceutical intervention."
>
> Problem is the otc drug is not a "nutraceutical intervention", it is a
> drug intervention because that substance is not found in foods at those
> pharmacological levels.
>
> An aspirin like substance can be found in willow bark. *If one chews it
> for pain relief is it a "nutraceutical intervention"?

http://www.youtube.com/watch?v=1NnEdcw6GhE&feature=fvw


On Nov 27, 3:18*pm, co...@lover.com wrote:
> not a "nutraceutical intervention", it is a * drug intervention
> because that substance is not found in foods at those
> pharmacological levels. <<
>
> "IF the resveratrol and polyphenol mixture is good at what it does then
> one could almost consider it to be an iron chelator mixture ..
>
> Therefore an .. iron reduction therapy .."
>
> Why dwell on undemonstrated "if" thinking? *The point was not what you
> speculate but that in the levels concerned it was no longer a
> "nutritional" substance that eating some food or another would provide.

On Nov 27, 6:24*am, ironjustice <teamtan...@hotmail.com> wrote:
> Molecular medicine in ophthalmic care.
> Richer S, Stiles W, Thomas C
> Optometry 2009 Dec; 80(12):695-701.
>
> BACKGROUND:
> Lipofuscin is the most consistent and phylogenically
> constant morphologic marker of cellular aging.
> Autofluorescence of the A2E fluorophore within
> retinal pigment epithelial (RPE) lipofuscin affords
> the opportunity for noninvasive evaluation of age-
> and disease-related pathophysiological changes in the
> human retina.
> It is being used in National Eye Institute/Age-Related
> Eye Disease Study II to evaluate age-related macular
> degeneration (AMD) geographic atrophy expansion.
> Experiments show lipofuscin can be reversed in cell
> culture and animal models in heart, brain, spinal cord,
> and retinal tissues, using an array of antioxidants
> and iron chelators.
> METHODS:
> An 80-year-old man with a gastric resection presented
> with complaints of unremitting night driving difficulty
> despite treatment with lutein and omega III fatty acids.

How stupid. First they induce the lipofuscin with the omega III fatty
acids and then they rush to treat it with the resveratrol .... I
wonder, are they doing this on purpose to increase the polyphenol
supplement sales or is this just plain idiocy?

Taka

> Notable parafoveal deposition of retinal lipofuscin by
> 50 degrees fundus auto-fluorescence
> (580 nm excitation/660 barrier filters) and concurrent
> abnormalities in non-Snellen measures of visual
> function-Contrast Sensitivity Function, 6.5 degrees
> large field tritan threshold, 10 degrees threshold visual
> fields, and deficits in the National Institutes of
> Health/National Eye Institute Visual Function Questionnaire
> (VFQ) 25 subjective night driving/mental health subscale
> questionnaire were obtained.
> The patient was placed on an over-the-counter daily oral
> polyphenolic mixture containing resveratrol and re-evaluated
> 5 months later.
> RESULTS: The data reveal improvements in all measures of
> visual function, subjective improvement in vision and mental
> functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
> CONCLUSION:
> To our knowledge, we believe this to be the first reported human
> clinical case of lipofuscin reversal in the human eye correlated
> with measured clinical and subjective improvement in visual and
> mental function after nutraceutical intervention.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

On Nov 27, 6:54*pm, Taka <taka0...@gmail.com> wrote:First they induce
the lipofuscin with the omega III fatty acids and then they rush to
treat it with the resveratrol .... I
wonder, are they doing this on purpose to increase the polyphenol
supplement sales or is this just plain idiocy? <<

He listens to what nutritionists
and dieticians and doctors and nurses tell them to do.
He was told to take fish oil "omega III fatty acids" ... INSTEAD of
the omega III fatty acids from plants.
It takes approximately three months for the 'change' to take place in
the body when one goes with the plant acids.
Evidenced by the schizophrenic recovery with plant fatty acids ..

Changes in erythrocyte membrane fatty acids during a clinical trial
of eicosapentaenoic acid (EPA) supplementation in schizophrenia.
Metab Brain Dis. 2009 Oct 14.
van Rensburg SJ, Smuts CM, Hon D, Kidd M, van der Merwe S,
Myburgh C, Oosthuizen P, Emsley R.


Division of Chemical Pathology, National Health Laboratory Service,
University of Stellenbosch, Stellenbosch, South Africa,
s...@sun.ac.za.


In a previously reported double-blind, placebo-controlled trial of
eicosapentaenoic acid (EPA) as supplemental treatment in 40 patients
with schizophrenia, we found significant improvement in symptoms as
measured by the Positive and Negative Syndrome Scale (PANSS)
compared to placebo (Emsley et al. 2002).
Here we report changes in fatty acid composition of erythrocyte
membranes in the same sample (n = 16 in each group).
After 12 weeks of receiving EPA, levels of several saturated and
mono-unsaturated fatty acids decreased significantly while levels of
n-3 fatty acids increased significantly compared to the placebo
group.
Increases of n-3 and n-6 fatty acids in the erythrocyte membranes
were
greater in subjects who improved more than 20% on overall symptoms.
Changes in fatty acids correlated significantly with improvement in
PANSS sub-scale scores, more so in females than in males.
Docosahexaenoic acid (DHA) (22:6n-3) levels increased less than
expected,
suggesting a possible defect in synthesis or incorporation of DHA
into
membranes in schizophrenia.
Improvement in dyskinesia correlated significantly with an increase
in
alpha-linolenic acid (18:3n-3; p = 0.03), and a decrease in 20:1n-9
(p
= 0.005).


PMID: 19826937
------------------



Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk

> On Nov 27, 6:24*am, ironjustice <teamtan...@hotmail.com> wrote:
>
>
>
>
>
> > Molecular medicine in ophthalmic care.
> > Richer S, Stiles W, Thomas C
> > Optometry 2009 Dec; 80(12):695-701.
>
> > BACKGROUND:
> > Lipofuscin is the most consistent and phylogenically
> > constant morphologic marker of cellular aging.
> > Autofluorescence of the A2E fluorophore within
> > retinal pigment epithelial (RPE) lipofuscin affords
> > the opportunity for noninvasive evaluation of age-
> > and disease-related pathophysiological changes in the
> > human retina.
> > It is being used in National Eye Institute/Age-Related
> > Eye Disease Study II to evaluate age-related macular
> > degeneration (AMD) geographic atrophy expansion.
> > Experiments show lipofuscin can be reversed in cell
> > culture and animal models in heart, brain, spinal cord,
> > and retinal tissues, using an array of antioxidants
> > and iron chelators.
> > METHODS:
> > An 80-year-old man with a gastric resection presented
> > with complaints of unremitting night driving difficulty
> > despite treatment with lutein and omega III fatty acids.
>
> How stupid. *First they induce the lipofuscin with the omega III fatty
> acids and then they rush to treat it with the resveratrol .... *I
> wonder, are they doing this on purpose to increase the polyphenol
> supplement sales or is this just plain idiocy?
>
> Taka
>
>
>
> > Notable parafoveal deposition of retinal lipofuscin by
> > 50 degrees fundus auto-fluorescence
> > (580 nm excitation/660 barrier filters) and concurrent
> > abnormalities in non-Snellen measures of visual
> > function-Contrast Sensitivity Function, 6.5 degrees
> > large field tritan threshold, 10 degrees threshold visual
> > fields, and deficits in the National Institutes of
> > Health/National Eye Institute Visual Function Questionnaire
> > (VFQ) 25 subjective night driving/mental health subscale
> > questionnaire were obtained.
> > The patient was placed on an over-the-counter daily oral
> > polyphenolic mixture containing resveratrol and re-evaluated
> > 5 months later.
> > RESULTS: The data reveal improvements in all measures of
> > visual function, subjective improvement in vision and mental
> > functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
> > CONCLUSION:
> > To our knowledge, we believe this to be the first reported human
> > clinical case of lipofuscin reversal in the human eye correlated
> > with measured clinical and subjective improvement in visual and
> > mental function after nutraceutical intervention.
>
> > Who loves ya.
> > Tom
>
> > Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> > Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> > DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk- Hide quoted text -
>
> - Show quoted text -- Hide quoted text -
>
> - Show quoted text -

On Nov 27, 12:18*pm, co...@lover.com wrote: Why dwell on
undemonstrated "if" thinking?
The point was not what you speculate but that in the levels concerned
it was no longer a
"nutritional" substance that eating some food or another would
provide.
not a "nutraceutical intervention", it is a * drug intervention
because that substance is not found in foods at those pharmacological
levels. <<

You are privy to the exact pharmaceutical intervention .. ?
In the human body there are deposits of iron.
When one eats a food containing a polyphenol .. there are polyphenols
in EVERY plant food .. and when one INCLUDES say plant oil WITH
quercitin the increased absorption by 100X was it .. ?
Soooo KNOWING that .. when one eats and EXCLUSIVE plant food diet ..
then the absorption OF these polyphenols will be ENHANCED simply
because the plants themselves contain the substances TOGETHER which
cause the 100X increased absorption.
Soooo by NOT eating any foods which CAUSE oxidation .. meat .. one
does not destroy the polyphenols or lipids found in the plant foods.
One simply digests the plant food normally without increased oxidation
from meat based food.

Sooo as in the schizophrenic study / three months to change the fatty
acid content and other studies which seem to point to three months to
increase the plant based fatty acids DISPLACING the meat based fatty
acids ..

Once one IS the lipid THEN the polyphenols which RESIDE in these fatty
acids which are destroyed by oxidation can disallow the oxidation to
take place ..

Polyphenols prevent oxidation ..

You DID know that .. ?

So .. in three months I believe that intervention CAN take place
through simple food manipulation..

IE: vegetarian / plant based diet sans milk cheese eggs / oxidation
causing food.

IF he wants to save his eyes ..

Theoretically ..

Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> "IF the resveratrol and polyphenol mixture is good at what it does then
> one could almost consider it to be an iron chelator mixture ..
>
> Therefore an .. iron reduction therapy .."
>
> Why dwell on undemonstrated "if" thinking? *The point was not what you
> speculate but that in the levels concerned it was no longer a
> "nutritional" substance that eating some food or another would provide.

On Nov 26, 1:24*pm, ironjustice <teamtan...@hotmail.com>
wrote:Experiments show lipofuscin can be reversed in cell culture and
animal models in heart, brain, spinal cord, and retinal tissues, using
an array of antioxidants and iron chelators.<<

"Need only about 1/100,000th the concentration of regular polyethylene
glycol"

New approach for repairing damaged nerve fibers in spinal cord
injuries using nano-spheres discovered
27. November 2009 01:11


Researchers at Purdue University have discovered a new approach for
repairing damaged nerve fibers in spinal cord injuries using nano-
spheres that could be injected into the blood shortly after an
accident.

The synthetic "copolymer micelles" are drug-delivery spheres about 60
nanometers in diameter, or roughly 100 times smaller than the diameter
of a red blood cell.

Researchers have been studying how to deliver drugs for cancer
treatment and other therapies using these spheres. Medications might
be harbored in the cores and ferried to diseased or damaged tissue.

Purdue researchers have now shown that the micelles themselves repair
damaged axons, fibers that transmit electrical impulses in the spinal
cord.

"That was a very surprising discovery," said Ji-Xin Cheng, an
associate professor in the Weldon School of Biomedical Engineering and
Department of Chemistry. "Micelles have been used for 30 years as drug-
delivery vehicles in research, but no one has ever used them directly
as a medicine."

Findings are detailed in a research paper appearing Sunday (Nov. 8) in
the journal Nature Nanotechnology.

A critical feature of micelles is that they combine two types of
polymers, one being hydrophobic and the other hydrophilic, meaning
they are either unable or able to mix with water. The hydrophobic core
can be loaded with drugs to treat disease.

The micelles might be used instead of more conventional "membrane
sealing agents," including polyethylene glycol, which makes up the
outer shell of the micelles. Because of the nanoscale size and the
polyethylene glycol shell of the micelles, they are not quickly
filtered by the kidney or captured by the liver, enabling them to
remain in the bloodstream long enough to circulate to damaged tissues.

In research led by biomedical engineering doctoral student Yunzhou
Shi, the micelles also were shown to be non-toxic at the
concentrations required.

"With the micelles, you need only about 1/100,000th the concentration
of regular polyethylene glycol," Cheng said.

Ongoing research at Purdue has shown the benefits of polyethylene
glycol, or PEG, to treat animals with spinal cord injuries. The work
is led by Richard Borgens, director of the Center for Paralysis
Research and the Mari Hulman George Professor of Neurology in the
School of Veterinary Medicine.

Findings have shown that PEG specifically targets damaged cells and
seals the injured area, reducing further damage. It also helps restore
cell function.

The new findings were made possible by the interdisciplinary nature of
the work, which involves Borgens and other Purdue researchers, Cheng
said. The collaboration included Borgens; Riyi Shi, an associate
professor of biomedical engineering and basic medical sciences; and
Kinam Park, Showalter Distinguished Professor of Biomedical
Engineering and a professor of pharmaceutics.

Findings showed that cores made of particular materials work better
than others at restoring function to damaged axons, which are slender
extensions of nerve cells.

The research also showed that without the micelles treatment about 18
percent of axons recover in a segment of damaged spinal cord tested in
a "double sucrose gap recording chamber." The micelles treatment
boosted the axon recovery to about 60 percent. The researchers used
the chamber to study how well micelles repaired damaged nerve cells by
measuring the "compound action potential," or the ability of a spinal
cord to transmit signals.

The experiment mimics what happens during a traumatic spinal cord
injury. Findings showed that micelles might be used to repair axon
membranes damaged by compression injuries, a common type of spine
injury.

The researchers also tracked dyed micelles in rats, demonstrating that
the nanoparticles were successfully delivered to injury sites.
Findings also showed micelles-treated animals recovered the
coordinated control of all four limbs, whereas animals treated with
conventional polyethylene glycol did not.


Source: Purdue University


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> Molecular medicine in ophthalmic care.
> Richer S, Stiles W, Thomas C
> Optometry 2009 Dec; 80(12):695-701.
>
> BACKGROUND:
> Lipofuscin is the most consistent and phylogenically
> constant morphologic marker of cellular aging.
> Autofluorescence of the A2E fluorophore within
> retinal pigment epithelial (RPE) lipofuscin affords
> the opportunity for noninvasive evaluation of age-
> and disease-related pathophysiological changes in the
> human retina.
> It is being used in National Eye Institute/Age-Related
> Eye Disease Study II to evaluate age-related macular
> degeneration (AMD) geographic atrophy expansion.
> Experiments show lipofuscin can be reversed in cell
> culture and animal models in heart, brain, spinal cord,
> and retinal tissues, using an array of antioxidants
> and iron chelators.
> METHODS:
> An 80-year-old man with a gastric resection presented
> with complaints of unremitting night driving difficulty
> despite treatment with lutein and omega III fatty acids.
> Notable parafoveal deposition of retinal lipofuscin by
> 50 degrees fundus auto-fluorescence
> (580 nm excitation/660 barrier filters) and concurrent
> abnormalities in non-Snellen measures of visual
> function-Contrast Sensitivity Function, 6.5 degrees
> large field tritan threshold, 10 degrees threshold visual
> fields, and deficits in the National Institutes of
> Health/National Eye Institute Visual Function Questionnaire
> (VFQ) 25 subjective night driving/mental health subscale
> questionnaire were obtained.
> The patient was placed on an over-the-counter daily oral
> polyphenolic mixture containing resveratrol and re-evaluated
> 5 months later.
> RESULTS: The data reveal improvements in all measures of
> visual function, subjective improvement in vision and mental
> functioning on the VFQ 25, and visible clearing of RPE lipofuscin.
> CONCLUSION:
> To our knowledge, we believe this to be the first reported human
> clinical case of lipofuscin reversal in the human eye correlated
> with measured clinical and subjective improvement in visual and
> mental function after nutraceutical intervention.
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk

On Nov 27, 8:26*pm, ironjustice <teamtan...@hotmail.com> wrote:
When one eats a food containing a polyphenol and when one
INCLUDES say plant oil <<

Phospholipid, oleic acid micelles and dietary olive
oil influence the lutein absorption and activity of
antioxidant enzymes in rats.
Lipids. 2009 Sep;44(9):799-806. Epub 2009 Aug 14
Lakshminarayana R, Raju M, Keshava Prakash MN, Baskaran V.

Department of Biochemistry and Nutrition,
Central Food Technological Research Institute, CSIR,
Mysore, 570020, India.

This study reports on the results of repeated gavages and
dietary feeding of lutein dispersed either in phospholipids
or fatty acid micelles or vegetable oils and the effects on
lutein bioavailability and antioxidant enzymes in rats.
For the gavage study, rats (n = 5/group) were intubated with
lutein solubilized either in oleic acid (OLA, 18:1n-9) or
linoleic acid (LNA, 18:2n-6) or phosphatidylcholine (PC) or
lysophosphatidylcholine (LPC) or no phospholipid (NoPL)
micelles for 10 days.
For the dietary study, rats (n = 5/group) were fed a diet
containing fenugreek leaf (lutein source), either with olive
(OO) or sunflower (SFO) or groundnut (GNO, control) oil or
L: -alpha-lecithin (PL) for 4 weeks.
The gavage study showed that the plasma, liver and eye lutein
levels in OLA and LPC groups were higher by 23.9, 20.8 and
25.5% and 16.1, 28.5 and 14.0% than LNA and PC groups,
respectively.
The dietary study showed the plasma (35.0 and 43.5%) and eye
(18.5 and 37.0%) lutein levels in OO were higher than SFO
and GNO groups.
The plasma and eye lutein levels in the PL group were higher
by 20 and 31.3% than in the control.
It is evident that OO and PL modulate lutein absorption,
which in turn modulates antioxidant enzymes and fatty acids
in plasma and tissues compared to SFO.
Hence, selection of the fat source may be vital to enhancing
the lutein bioavailability.

PMID: 19685091


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> On Nov 27, 12:18*pm, co...@lover.com wrote: Why dwell on
> undemonstrated "if" thinking?
> The point was not what you speculate but that in the levels concerned
> it was no longer a
> "nutritional" substance that eating some food or another would
> provide.
> not a "nutraceutical intervention", it is a * drug intervention
> because that substance is not found in foods at those pharmacological
> levels. <<
>
> You are privy to the exact pharmaceutical intervention .. ?
> In the human body there are deposits of iron.
> When one eats a food containing a polyphenol .. there are polyphenols
> in EVERY plant food .. and when one INCLUDES say plant oil WITH
> quercitin the increased absorption by 100X was it .. ?
> Soooo KNOWING that .. when one eats and EXCLUSIVE plant food diet ..
> then the absorption OF these polyphenols will be ENHANCED simply
> because the plants themselves contain the substances TOGETHER which
> cause the 100X increased absorption.
> Soooo by NOT eating any foods which CAUSE oxidation .. meat .. one
> does not destroy the polyphenols or lipids found in the plant foods.
> One simply digests the plant food normally without increased oxidation
> from meat based food.
>
> Sooo as in the schizophrenic study / three months to change the fatty
> acid content and other studies which seem to point to three months to
> increase the plant based fatty acids DISPLACING the meat based fatty
> acids ..
>
> Once one IS the lipid THEN the polyphenols which RESIDE in these fatty
> acids which are destroyed by oxidation can disallow the oxidation to
> take place ..
>
> Polyphenols prevent oxidation ..
>
> You DID know that .. ?
>
> So .. in three months I believe that intervention CAN take place
> through simple food manipulation..
>
> IE: vegetarian / plant based diet sans milk cheese eggs / oxidation
> causing food.
>
> IF he wants to save his eyes ..
>
> Theoretically ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > "IF the resveratrol and polyphenol mixture is good at what it does then
> > one could almost consider it to be an iron chelator mixture ..
>
> > Therefore an .. iron reduction therapy .."
>
> > Why dwell on undemonstrated "if" thinking? *The point was not what you
> > speculate but that in the levels concerned it was no longer a
> > "nutritional" substance that eating some food or another would provide.- Hide quoted text -
>
> - Show quoted text -

On Nov 27, 8:26*pm, ironjustice <teamtan...@hotmail.com> wrote:
by NOT eating any foods which CAUSE oxidation .. meat .. one
does not destroy the polyphenols or lipids found in the plant foods.
<<

Iron decreases the antioxidant capacity of red wine under conditions
of
in vitro digestion
Konstantina Argyri, Michael Komaitis and Maria Kapsokefalou,
Department of Food Science and Technology, Agricultural University of
Athens, Iera Odos 75, 11855 Athens, Greece
Received 12 July 2004; revised 15 February 2005; accepted 15
February
2005. Available online 28 April 2005.

Abstract
The hypothesis that iron and phenolics interact in the lumen during
digestion and, consequently, decrease the antioxidant capacity of
phenolics, was investigated in vitro.
Mixtures of red wine, iron, and three dietary factors that may
reduce or chelate iron in the lumen, namely ascorbic acid, meat and
casein, were subjected to a simulated gastrointestinal digestion.
The process involved incubation of samples for 4.5 h at 37 °C, at
different pHs, in the presence of peptic enzymes and fractionation
of digests through a dialysis membrane.
Antioxidant capacity (FRAP assay), iron concentration (ferrozine
assay)
and total phenolic content (Folin-Ciocalteau assay) were measured in
the in vitro digests.
Iron decreased the antioxidant capacity and the total phenolic
concentration of red wine.
Ascorbic acid increased, while meat and casein decreased, the
antioxidant capacity of red wine.
Based on these results, it was concluded that protein and iron
interact
with red wine phenolics during the in vitro digestion and decrease
their antioxidant capacity, supporting the initial hypothesis.


Keywords: Phenolics; Wine; Antioxidants; Iron; In vitro digestion


Corresponding author. Tel./fax: +30 210 5294708.


Food Chemistry
Volume 96, Issue 2 , May 2006, Pages 281-289


Who loves ya.
Tom


Jesus Was A Vegetarian!
http://tinyurl.com/2r2nkh


Man Is A Herbivore!
http://tinyurl.com/a3cc3


DEAD PEOPLE WALKING
http://tinyurl.com/zk9fk


> On Nov 27, 12:18*pm, co...@lover.com wrote: Why dwell on
> undemonstrated "if" thinking?
> The point was not what you speculate but that in the levels concerned
> it was no longer a
> "nutritional" substance that eating some food or another would
> provide.
> not a "nutraceutical intervention", it is a * drug intervention
> because that substance is not found in foods at those pharmacological
> levels. <<
>
> You are privy to the exact pharmaceutical intervention .. ?
> In the human body there are deposits of iron.
> When one eats a food containing a polyphenol .. there are polyphenols
> in EVERY plant food .. and when one INCLUDES say plant oil WITH
> quercitin the increased absorption by 100X was it .. ?
> Soooo KNOWING that .. when one eats and EXCLUSIVE plant food diet ..
> then the absorption OF these polyphenols will be ENHANCED simply
> because the plants themselves contain the substances TOGETHER which
> cause the 100X increased absorption.
> Soooo by NOT eating any foods which CAUSE oxidation .. meat .. one
> does not destroy the polyphenols or lipids found in the plant foods.
> One simply digests the plant food normally without increased oxidation
> from meat based food.
>
> Sooo as in the schizophrenic study / three months to change the fatty
> acid content and other studies which seem to point to three months to
> increase the plant based fatty acids DISPLACING the meat based fatty
> acids ..
>
> Once one IS the lipid THEN the polyphenols which RESIDE in these fatty
> acids which are destroyed by oxidation can disallow the oxidation to
> take place ..
>
> Polyphenols prevent oxidation ..
>
> You DID know that .. ?
>
> So .. in three months I believe that intervention CAN take place
> through simple food manipulation..
>
> IE: vegetarian / plant based diet sans milk cheese eggs / oxidation
> causing food.
>
> IF he wants to save his eyes ..
>
> Theoretically ..
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!http://tinyurl.com/2r2nkh
>
> Man Is A Herbivore!http://tinyurl.com/a3cc3
>
> DEAD PEOPLE WALKINGhttp://tinyurl.com/zk9fk
>
>
>
> > "IF the resveratrol and polyphenol mixture is good at what it does then
> > one could almost consider it to be an iron chelator mixture ..
>
> > Therefore an .. iron reduction therapy .."
>
> > Why dwell on undemonstrated "if" thinking? *The point was not what you
> > speculate but that in the levels concerned it was no longer a
> > "nutritional" substance that eating some food or another would provide.- Hide quoted text -
>
> - Show quoted text -