I suppose this would be to offset the high hemoglobin found in those with diabetes .. Dexamethasone Implants Improve Diabetic Macular Edema http://www.medscape.com/viewarticle/718820 NEW YORK (Reuters Health) Mar 18 - An intravitreal dexamethasone delivery system improves diabetic macular edema, researchers report in the March issue of Archives of Ophthalmology. The intravitreal implant (Ozurdex, Allergan) contains dexamethasone in a solid polymer drug delivery system. Literature from its manufacturer says that in earlier clinical trials, 20% to 30% of patients had at least a 15-letter (3 lines) improvement in best-corrected visual acuity within two months after implantation, with improvements lasting "approximately one to three months after onset of this effect." In the current study, Dr. Julia A. Haller of the Wills Eye Institute, Philadelphia, and colleagues focused on 171 clinical trial subjects with persistent diabetic macular edema (one eye in each person). The phase II trial had three arms: a 250 ug dexamethasone implant, a 700 ug system, or observation only. At 90 days, 33.3% of the 700 ug group, 21.1% of the 250 ug group, and 12.3% of controls had improvements of at least 10 letters in their best-corrected visual acuity. The difference between the higher dose implant and observation was statistically significant at days 60 and 90. At 180 days, the visual acuity improvement persisted in 30% of the 700 ug group, 19% of the 350 ug group, and 23% of the observation group; at this point, the differences were no longer significant. Both treatment groups had significant improvements in central retinal thickness and fluorescein leakage compared with the observation group. The implants were well tolerated, Dr. Haller told Reuters Health by email, and they appear "to be a promising new treatment option for eyes with persistent diabetic macular edema." The trial was sponsored by Oculex Pharmaceuticals (developer of the Ozurdex system) and Allergan, the parent company of Oculex. Arch Ophthalmol 2010;128:289-296. ------------------ ------------- "Inhibitory effect of dexamethasone on in vivo erythropoiesis" "Erythropoietic depression was elicited by cyclophosphamide administration" It's curious how these VERY popular drugs .. reduce blood cell count. Reduce the number of red blood cells. Somewhat like .. bloodletting. Enhanced hypoxia-stimulated erythropoietin production in mice with depression of erythropoiesis induced by hyperoxia. High Alt Med Biol. 2003 Spring;4(1):73-9. Bozzini CE, Barceló AC, Conti MI, Martínez MP, Alippi RM. Department of Physiology, Faculty of Odontology, University of Buenos Aires, Argentina. Current evidence suggests that a modulatory action on O(2)-dependent EPO secretion is exerted by the erythroid/precursor cell population in the erythropoietic organs through a negative feedback system. The hypothesis is based on studies of stimulated-EPO secretion performed in mice in whom the erythropoietic rates were either enhanced or depressed in the presence of normal plasma EPO half- lives. Since erythropoietic depression was elicited by cyclophosphamide administration, which could have altered EPO production directly, the aim of the present investigation was to estimate hypoxia-stimulated EPO secretion in a mouse model of functional depressed erythropoiesis induced by exposure to normobaric hyperoxia. Females CF#1 mice aged 70 d were divided into control (C) and experimental (E) groups. The former was maintained in plastic cages in a normal environment, while the latter was placed in an environment of 60% O(2)/40% N(2) in an 85-dm(3) atmospheric chamber with air flow of 1 L/min. Erythropoiesis was evaluated by either 24-h RBC-(59)Fe uptake or iron kinetics performed 3 h after IV injection of a tracer dose of (59)Fe. Both indexes of the red cell production rate were significantly depressed in E mice. Plasma disappearance of exogenous EPO in C mice, as well as in E mice exposed to hyperoxia for 4 d, was estimated by injecting (125)I-rHuEPO intravenously. Linear regression analysis indicated that neither the differences between the slopes of both curves nor the Y-intercepts were significant. Hypobaric hypoxemia was used as stimulus for EPO production. Plasma immuno-EPO titer after a 4-h exposure to hypobaric air was 73% higher in mice with hyperoxia-induced hypoerythropoiesis than in control mice with normal erythropoiesis. Data support the concept that the rate of erythropoiesis, perhaps through the number of the erythroid progenitor/precursor cell population, modulates O(2)-dependent EPO secretion. PMID: 12713714 ------------------- Exp Hematol. 1980 Aug ;8 (7):911-6 16398023 (P,S,G,E,B) Mechanism underlying the inhibitory effect of dexamethasone on in vivo erythropoiesis. [My paper] M J Giglio, R M Alippi, C E Bozzini Cátedras de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, República Argentina. The time-response curve for RBC-59Fe uptake following i.p. injection of 5 mg of dexamethasone into normal, non-polycythemic mice, shows a maximal depression (50% of normal) at 3 days after dexamethasone with return to almost normal values by 5 days. The effect is dose-related showing a plateau with doses of dexamethasone above 3 mg. The shape of the time-response curve indicates that the more mature cells in the erythron are not affected by dexamethasone and that the major effect of the steroid must be on earlier erythroid cells. Intravenous injection of dexamethasone 33 and 48 h after i.v. injection of erythropoietin in post-hypoxic polycythemic mice has no effect on the response to erythropoietin, suggesting that the early and late erythroblasts develop normally into erythrocytes. Injection of dexamethasone 13 h after erythropoietin is also ineffective, suggesting that the final steps of differentiation from erythropoietin responsive cells (ERC) to proerythroblasts are not affected. On the contrary, injection of dexamethasone 1 h after erythropoietin reduces by 60% the effective erythropoiesis, which can be attributed to a decrease in differentiation of ERC into proerythroblasts. These results indicate that the inhibitory action of dexamethasone on erythropoiesis is exerted on cells of the erythroid line before the stage of proerythroblast is reached. Mesh-terms: Animals; Anti-Inflammatory Agents :: administration & dosage; Cell Differentiation :: drug effects; Cells, Cultured; Colony- Forming Units Assay; Dexamethasone :: administration & dosage; Dose- Response Relationship, Drug; Erythroblasts :: cytology; Erythroblasts :: physiology; Erythropoiesis :: drug effects; Erythropoietin :: administration & dosage; Female; Mice; Research Support, Non-U.S. Gov't; Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Rusty you are worse than worthless, you are causing actual harm in your monomaniacal psychosis trying to "prove" that all the world's ills are caused by excess iron/eating meat/using iron chelating drugs to treat everything. I suggest you seek treatment. David.
On Mar 21, 8:45 am, "" <> wrote: I suggest you seek treatment. << I suggest you grow some balls .. That ain't gonna happen .. Heh .. heh .. I suppose this would be to offset the high hemoglobin found in those with diabetes .. Dexamethasone Implants Improve Diabetic Macular Edema http://www.medscape.com/viewarticle/718820 NEW YORK (Reuters Health) Mar 18 - An intravitreal dexamethasone delivery system improves diabetic macular edema, researchers report in the March issue of Archives of Ophthalmology. The intravitreal implant (Ozurdex, Allergan) contains dexamethasone in a solid polymer drug delivery system. Literature from its manufacturer says that in earlier clinical trials, 20% to 30% of patients had at least a 15-letter (3 lines) improvement in best-corrected visual acuity within two months after implantation, with improvements lasting "approximately one to three months after onset of this effect." In the current study, Dr. Julia A. Haller of the Wills Eye Institute, Philadelphia, and colleagues focused on 171 clinical trial subjects with persistent diabetic macular edema (one eye in each person). The phase II trial had three arms: a 250 ug dexamethasone implant, a 700 ug system, or observation only. At 90 days, 33.3% of the 700 ug group, 21.1% of the 250 ug group, and 12.3% of controls had improvements of at least 10 letters in their best-corrected visual acuity. The difference between the higher dose implant and observation was statistically significant at days 60 and 90. At 180 days, the visual acuity improvement persisted in 30% of the 700 ug group, 19% of the 350 ug group, and 23% of the observation group; at this point, the differences were no longer significant. Both treatment groups had significant improvements in central retinal thickness and fluorescein leakage compared with the observation group. The implants were well tolerated, Dr. Haller told Reuters Health by email, and they appear "to be a promising new treatment option for eyes with persistent diabetic macular edema." The trial was sponsored by Oculex Pharmaceuticals (developer of the Ozurdex system) and Allergan, the parent company of Oculex. Arch Ophthalmol 2010;128:289-296. ------------------ ------------- "Inhibitory effect of dexamethasone on in vivo erythropoiesis" "Erythropoietic depression was elicited by cyclophosphamide administration" It's curious how these VERY popular drugs .. reduce blood cell count. Reduce the number of red blood cells. Somewhat like .. bloodletting. Enhanced hypoxia-stimulated erythropoietin production in mice with depression of erythropoiesis induced by hyperoxia. High Alt Med Biol. 2003 Spring;4(1):73-9. Bozzini CE, Barceló AC, Conti MI, Martínez MP, Alippi RM. Department of Physiology, Faculty of Odontology, University of Buenos Aires, Argentina. Current evidence suggests that a modulatory action on O(2)-dependent EPO secretion is exerted by the erythroid/precursor cell population in the erythropoietic organs through a negative feedback system. The hypothesis is based on studies of stimulated-EPO secretion performed in mice in whom the erythropoietic rates were either enhanced or depressed in the presence of normal plasma EPO half- lives. Since erythropoietic depression was elicited by cyclophosphamide administration, which could have altered EPO production directly, the aim of the present investigation was to estimate hypoxia-stimulated EPO secretion in a mouse model of functional depressed erythropoiesis induced by exposure to normobaric hyperoxia. Females CF#1 mice aged 70 d were divided into control (C) and experimental (E) groups. The former was maintained in plastic cages in a normal environment, while the latter was placed in an environment of 60% O(2)/40% N(2) in an 85-dm(3) atmospheric chamber with air flow of 1 L/min. Erythropoiesis was evaluated by either 24-h RBC-(59)Fe uptake or iron kinetics performed 3 h after IV injection of a tracer dose of (59)Fe. Both indexes of the red cell production rate were significantly depressed in E mice. Plasma disappearance of exogenous EPO in C mice, as well as in E mice exposed to hyperoxia for 4 d, was estimated by injecting (125)I-rHuEPO intravenously. Linear regression analysis indicated that neither the differences between the slopes of both curves nor the Y-intercepts were significant. Hypobaric hypoxemia was used as stimulus for EPO production. Plasma immuno-EPO titer after a 4-h exposure to hypobaric air was 73% higher in mice with hyperoxia-induced hypoerythropoiesis than in control mice with normal erythropoiesis. Data support the concept that the rate of erythropoiesis, perhaps through the number of the erythroid progenitor/precursor cell population, modulates O(2)-dependent EPO secretion. PMID: 12713714 ------------------- Exp Hematol. 1980 Aug ;8 (7):911-6 16398023 (P,S,G,E,B) Mechanism underlying the inhibitory effect of dexamethasone on in vivo erythropoiesis. [My paper] M J Giglio, R M Alippi, C E Bozzini Cátedras de Fisiología, Facultad de Odontología, Universidad de Buenos Aires, República Argentina. The time-response curve for RBC-59Fe uptake following i.p. injection of 5 mg of dexamethasone into normal, non-polycythemic mice, shows a maximal depression (50% of normal) at 3 days after dexamethasone with return to almost normal values by 5 days. The effect is dose-related showing a plateau with doses of dexamethasone above 3 mg. The shape of the time-response curve indicates that the more mature cells in the erythron are not affected by dexamethasone and that the major effect of the steroid must be on earlier erythroid cells. Intravenous injection of dexamethasone 33 and 48 h after i.v. injection of erythropoietin in post-hypoxic polycythemic mice has no effect on the response to erythropoietin, suggesting that the early and late erythroblasts develop normally into erythrocytes. Injection of dexamethasone 13 h after erythropoietin is also ineffective, suggesting that the final steps of differentiation from erythropoietin responsive cells (ERC) to proerythroblasts are not affected. On the contrary, injection of dexamethasone 1 h after erythropoietin reduces by 60% the effective erythropoiesis, which can be attributed to a decrease in differentiation of ERC into proerythroblasts. These results indicate that the inhibitory action of dexamethasone on erythropoiesis is exerted on cells of the erythroid line before the stage of proerythroblast is reached. Mesh-terms: Animals; Anti-Inflammatory Agents :: administration & dosage; Cell Differentiation :: drug effects; Cells, Cultured; Colony- Forming Units Assay; Dexamethasone :: administration & dosage; Dose- Response Relationship, Drug; Erythroblasts :: cytology; Erythroblasts :: physiology; Erythropoiesis :: drug effects; Erythropoietin :: administration & dosage; Female; Mice; Research Support, Non-U.S. Gov't; Who loves ya. Tom Jesus Was A Vegetarian! http://tinyurl.com/2r2nkh Man Is A Herbivore! http://tinyurl.com/a3cc3 DEAD PEOPLE WALKING http://tinyurl.com/zk9fk
Who let the dogs in? -- "Fascism should more properly be called corporatism because it is the merger of state and corporate power." - Benito Mussolini. http://www.thirdworldtraveler.com/Zinn/HZinn_page.html
