Altitude Drug For Diabetic Eye

Discussion in 'Optometry Archives' started by ironjustice, Mar 20, 2010.

  1. ironjustice

    ironjustice Guest

    I suppose this would be to offset the high hemoglobin found in those
    with
    diabetes ..

    Dexamethasone Implants Improve Diabetic Macular Edema

    http://www.medscape.com/viewarticle/718820

    NEW YORK (Reuters Health) Mar 18 - An intravitreal dexamethasone
    delivery system improves diabetic macular edema, researchers report in
    the March issue of Archives of Ophthalmology.

    The intravitreal implant (Ozurdex, Allergan) contains dexamethasone in
    a solid polymer drug delivery system. Literature from its manufacturer
    says that in earlier clinical trials, 20% to 30% of patients had at
    least a 15-letter (3 lines) improvement in best-corrected visual
    acuity within two months after implantation, with improvements lasting
    "approximately one to three months after onset of this effect."

    In the current study, Dr. Julia A. Haller of the Wills Eye Institute,
    Philadelphia, and colleagues focused on 171 clinical trial subjects
    with persistent diabetic macular edema (one eye in each person). The
    phase II trial had three arms: a 250 ug dexamethasone implant, a 700
    ug system, or observation only.

    At 90 days, 33.3% of the 700 ug group, 21.1% of the 250 ug group, and
    12.3% of controls had improvements of at least 10 letters in their
    best-corrected visual acuity.

    The difference between the higher dose implant and observation was
    statistically significant at days 60 and 90. At 180 days, the visual
    acuity improvement persisted in 30% of the 700 ug group, 19% of the
    350 ug group, and 23% of the observation group; at this point, the
    differences were no longer significant.

    Both treatment groups had significant improvements in central retinal
    thickness and fluorescein leakage compared with the observation group.

    The implants were well tolerated, Dr. Haller told Reuters Health by
    email, and they appear "to be a promising new treatment option for
    eyes with persistent diabetic macular edema."

    The trial was sponsored by Oculex Pharmaceuticals (developer of the
    Ozurdex system) and Allergan, the parent company of Oculex.

    Arch Ophthalmol 2010;128:289-296.
    ------------------

    -------------

    "Inhibitory effect of dexamethasone on in vivo erythropoiesis"

    "Erythropoietic depression was elicited by cyclophosphamide
    administration"


    It's curious how these VERY popular drugs .. reduce blood cell count.
    Reduce the number of red blood cells.
    Somewhat like .. bloodletting.


    Enhanced hypoxia-stimulated erythropoietin production in mice with
    depression of erythropoiesis induced by hyperoxia.
    High Alt Med Biol. 2003 Spring;4(1):73-9.
    Bozzini CE, Barceló AC, Conti MI, Martínez MP, Alippi RM.
    Department of Physiology, Faculty of Odontology, University of Buenos
    Aires, Argentina.


    Current evidence suggests that a modulatory action on O(2)-dependent
    EPO secretion is exerted by the erythroid/precursor cell population
    in
    the erythropoietic organs through a negative feedback system.
    The hypothesis is based on studies of stimulated-EPO secretion
    performed in mice in whom the erythropoietic rates were either
    enhanced or depressed in the presence of normal plasma EPO half-
    lives.
    Since erythropoietic depression was elicited by cyclophosphamide
    administration, which could have altered EPO production directly, the
    aim of the present investigation was to estimate hypoxia-stimulated
    EPO secretion in a mouse model of functional depressed erythropoiesis
    induced by exposure to normobaric hyperoxia.
    Females CF#1 mice aged 70 d were divided into control (C) and
    experimental (E) groups.
    The former was maintained in plastic cages in a normal environment,
    while the latter was placed in an environment of 60% O(2)/40% N(2) in
    an 85-dm(3) atmospheric chamber with air flow of 1 L/min.
    Erythropoiesis was evaluated by either 24-h RBC-(59)Fe uptake or iron
    kinetics performed 3 h after IV injection of a tracer dose of (59)Fe.
    Both indexes of the red cell production rate were significantly
    depressed in E mice. Plasma disappearance of exogenous EPO in C mice,
    as well as in E mice exposed to hyperoxia for 4 d, was estimated by
    injecting (125)I-rHuEPO intravenously.
    Linear regression analysis indicated that neither the differences
    between the slopes of both curves nor the Y-intercepts were
    significant.
    Hypobaric hypoxemia was used as stimulus for EPO production.
    Plasma immuno-EPO titer after a 4-h exposure to hypobaric air was 73%
    higher in mice with hyperoxia-induced hypoerythropoiesis than in
    control mice with normal erythropoiesis.
    Data support the concept that the rate of erythropoiesis, perhaps
    through the number of the erythroid progenitor/precursor cell
    population, modulates O(2)-dependent EPO secretion.


    PMID: 12713714


    -------------------


    Exp Hematol. 1980 Aug ;8 (7):911-6 16398023 (P,S,G,E,B) Mechanism
    underlying the inhibitory effect of dexamethasone on in vivo
    erythropoiesis.


    [My paper] M J Giglio, R M Alippi, C E Bozzini
    Cátedras de Fisiología, Facultad de Odontología, Universidad de
    Buenos
    Aires, República Argentina.
    The time-response curve for RBC-59Fe uptake following i.p. injection
    of 5 mg of dexamethasone into normal, non-polycythemic mice, shows a
    maximal depression (50% of normal) at 3 days after dexamethasone with
    return to almost normal values by 5 days. The effect is dose-related
    showing a plateau with doses of dexamethasone above 3 mg. The shape
    of
    the time-response curve indicates that the more mature cells in the
    erythron are not affected by dexamethasone and that the major effect
    of the steroid must be on earlier erythroid cells. Intravenous
    injection of dexamethasone 33 and 48 h after i.v. injection of
    erythropoietin in post-hypoxic polycythemic mice has no effect on the
    response to erythropoietin, suggesting that the early and late
    erythroblasts develop normally into erythrocytes. Injection of
    dexamethasone 13 h after erythropoietin is also ineffective,
    suggesting that the final steps of differentiation from
    erythropoietin
    responsive cells (ERC) to proerythroblasts are not affected. On the
    contrary, injection of dexamethasone 1 h after erythropoietin reduces
    by 60% the effective erythropoiesis, which can be attributed to a
    decrease in differentiation of ERC into proerythroblasts. These
    results indicate that the inhibitory action of dexamethasone on
    erythropoiesis is exerted on cells of the erythroid line before the
    stage of proerythroblast is reached.
    Mesh-terms: Animals; Anti-Inflammatory Agents :: administration &
    dosage; Cell Differentiation :: drug effects; Cells, Cultured;
    Colony-
    Forming Units Assay; Dexamethasone :: administration & dosage; Dose-
    Response Relationship, Drug; Erythroblasts :: cytology;
    Erythroblasts :: physiology; Erythropoiesis :: drug effects;
    Erythropoietin :: administration & dosage; Female; Mice; Research
    Support, Non-U.S. Gov't;


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk
     
    ironjustice, Mar 20, 2010
    #1
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  2. ironjustice

    Ken Guest

    Spamming Canuck Cocksucker
     
    Ken, Mar 20, 2010
    #2
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  3. ironjustice

    Happy Oyster Guest


    ditto.

    ..
     
    Happy Oyster, Mar 21, 2010
    #3
  4. ironjustice

    Guest

    Rusty you are worse than worthless, you are causing actual harm in
    your monomaniacal psychosis trying to "prove" that all the world's
    ills are caused by excess iron/eating meat/using iron chelating drugs
    to treat everything.

    I suggest you seek treatment.

    David.
     
    , Mar 21, 2010
    #4
  5. ironjustice

    ironjustice Guest

    On Mar 21, 8:45 am, "" <>
    wrote:
    I suggest you seek treatment.
    <<

    I suggest you grow some balls ..

    That ain't gonna happen ..

    Heh .. heh ..

    I suppose this would be to offset the high hemoglobin found in those
    with
    diabetes ..

    Dexamethasone Implants Improve Diabetic Macular Edema


    http://www.medscape.com/viewarticle/718820


    NEW YORK (Reuters Health) Mar 18 - An intravitreal dexamethasone
    delivery system improves diabetic macular edema, researchers report
    in
    the March issue of Archives of Ophthalmology.


    The intravitreal implant (Ozurdex, Allergan) contains dexamethasone
    in
    a solid polymer drug delivery system. Literature from its
    manufacturer
    says that in earlier clinical trials, 20% to 30% of patients had at
    least a 15-letter (3 lines) improvement in best-corrected visual
    acuity within two months after implantation, with improvements
    lasting
    "approximately one to three months after onset of this effect."


    In the current study, Dr. Julia A. Haller of the Wills Eye Institute,
    Philadelphia, and colleagues focused on 171 clinical trial subjects
    with persistent diabetic macular edema (one eye in each person). The
    phase II trial had three arms: a 250 ug dexamethasone implant, a 700
    ug system, or observation only.


    At 90 days, 33.3% of the 700 ug group, 21.1% of the 250 ug group, and
    12.3% of controls had improvements of at least 10 letters in their
    best-corrected visual acuity.


    The difference between the higher dose implant and observation was
    statistically significant at days 60 and 90. At 180 days, the visual
    acuity improvement persisted in 30% of the 700 ug group, 19% of the
    350 ug group, and 23% of the observation group; at this point, the
    differences were no longer significant.


    Both treatment groups had significant improvements in central retinal
    thickness and fluorescein leakage compared with the observation
    group.


    The implants were well tolerated, Dr. Haller told Reuters Health by
    email, and they appear "to be a promising new treatment option for
    eyes with persistent diabetic macular edema."


    The trial was sponsored by Oculex Pharmaceuticals (developer of the
    Ozurdex system) and Allergan, the parent company of Oculex.


    Arch Ophthalmol 2010;128:289-296.
    ------------------


    -------------


    "Inhibitory effect of dexamethasone on in vivo erythropoiesis"


    "Erythropoietic depression was elicited by cyclophosphamide
    administration"


    It's curious how these VERY popular drugs .. reduce blood cell count.
    Reduce the number of red blood cells.
    Somewhat like .. bloodletting.


    Enhanced hypoxia-stimulated erythropoietin production in mice with
    depression of erythropoiesis induced by hyperoxia.
    High Alt Med Biol. 2003 Spring;4(1):73-9.
    Bozzini CE, Barceló AC, Conti MI, Martínez MP, Alippi RM.
    Department of Physiology, Faculty of Odontology, University of Buenos
    Aires, Argentina.


    Current evidence suggests that a modulatory action on O(2)-dependent
    EPO secretion is exerted by the erythroid/precursor cell population
    in
    the erythropoietic organs through a negative feedback system.
    The hypothesis is based on studies of stimulated-EPO secretion
    performed in mice in whom the erythropoietic rates were either
    enhanced or depressed in the presence of normal plasma EPO half-
    lives.
    Since erythropoietic depression was elicited by cyclophosphamide
    administration, which could have altered EPO production directly, the
    aim of the present investigation was to estimate hypoxia-stimulated
    EPO secretion in a mouse model of functional depressed erythropoiesis
    induced by exposure to normobaric hyperoxia.
    Females CF#1 mice aged 70 d were divided into control (C) and
    experimental (E) groups.
    The former was maintained in plastic cages in a normal environment,
    while the latter was placed in an environment of 60% O(2)/40% N(2) in
    an 85-dm(3) atmospheric chamber with air flow of 1 L/min.
    Erythropoiesis was evaluated by either 24-h RBC-(59)Fe uptake or iron
    kinetics performed 3 h after IV injection of a tracer dose of (59)Fe.
    Both indexes of the red cell production rate were significantly
    depressed in E mice. Plasma disappearance of exogenous EPO in C mice,
    as well as in E mice exposed to hyperoxia for 4 d, was estimated by
    injecting (125)I-rHuEPO intravenously.
    Linear regression analysis indicated that neither the differences
    between the slopes of both curves nor the Y-intercepts were
    significant.
    Hypobaric hypoxemia was used as stimulus for EPO production.
    Plasma immuno-EPO titer after a 4-h exposure to hypobaric air was 73%
    higher in mice with hyperoxia-induced hypoerythropoiesis than in
    control mice with normal erythropoiesis.
    Data support the concept that the rate of erythropoiesis, perhaps
    through the number of the erythroid progenitor/precursor cell
    population, modulates O(2)-dependent EPO secretion.


    PMID: 12713714


    -------------------


    Exp Hematol. 1980 Aug ;8 (7):911-6 16398023 (P,S,G,E,B) Mechanism
    underlying the inhibitory effect of dexamethasone on in vivo
    erythropoiesis.


    [My paper] M J Giglio, R M Alippi, C E Bozzini
    Cátedras de Fisiología, Facultad de Odontología, Universidad de
    Buenos
    Aires, República Argentina.
    The time-response curve for RBC-59Fe uptake following i.p. injection
    of 5 mg of dexamethasone into normal, non-polycythemic mice, shows a
    maximal depression (50% of normal) at 3 days after dexamethasone with
    return to almost normal values by 5 days. The effect is dose-related
    showing a plateau with doses of dexamethasone above 3 mg. The shape
    of
    the time-response curve indicates that the more mature cells in the
    erythron are not affected by dexamethasone and that the major effect
    of the steroid must be on earlier erythroid cells. Intravenous
    injection of dexamethasone 33 and 48 h after i.v. injection of
    erythropoietin in post-hypoxic polycythemic mice has no effect on the
    response to erythropoietin, suggesting that the early and late
    erythroblasts develop normally into erythrocytes. Injection of
    dexamethasone 13 h after erythropoietin is also ineffective,
    suggesting that the final steps of differentiation from
    erythropoietin
    responsive cells (ERC) to proerythroblasts are not affected. On the
    contrary, injection of dexamethasone 1 h after erythropoietin reduces
    by 60% the effective erythropoiesis, which can be attributed to a
    decrease in differentiation of ERC into proerythroblasts. These
    results indicate that the inhibitory action of dexamethasone on
    erythropoiesis is exerted on cells of the erythroid line before the
    stage of proerythroblast is reached.
    Mesh-terms: Animals; Anti-Inflammatory Agents :: administration &
    dosage; Cell Differentiation :: drug effects; Cells, Cultured;
    Colony-
    Forming Units Assay; Dexamethasone :: administration & dosage; Dose-
    Response Relationship, Drug; Erythroblasts :: cytology;
    Erythroblasts :: physiology; Erythropoiesis :: drug effects;
    Erythropoietin :: administration & dosage; Female; Mice; Research
    Support, Non-U.S. Gov't;


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk
     
    ironjustice, Mar 21, 2010
    #5
  6. ironjustice

    Ken Guest

    Spamming Canuck Dicksucker
     
    Ken, Mar 21, 2010
    #6
  7. ironjustice

    Billy Guest

    Who let the dogs in?
    --
    "Fascism should more properly be called corporatism because it is the
    merger of state and corporate power." - Benito Mussolini.


    http://www.thirdworldtraveler.com/Zinn/HZinn_page.html
     
    Billy, Mar 22, 2010
    #7
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