Eye Trauma Treatment

Discussion in 'Optometry Archives' started by ironjustice, Apr 13, 2009.

  1. ironjustice

    ironjustice Guest

    http://www.escrs.org/EVENTS/06LONDON/posters.asp?session=ALL

    Effectiveness of Lipophlavon for the complex treatment of trauma
    keratitis
    Medical Science; 2006.
    A. Petrunya , F. I. S. Ashour
    Lugansk State Medical University,
    Lugansk, Ukraine
    Deutsche Ophthalmologische Gesellschaft e.V..

    Background
    Treatment of patients with trauma keratitis represents a significant
    problem encountered in the eye clinic, and yet the management of this
    condition has not been effective so far. The abstract presents data on
    clinical trial of a new liposome eye medication Lipophlavon,
    containing antioxidant, kvertsetin, phosphatidilholine lecitin, its
    effectiveness for the complex treatment of trauma keratitis.
    Aims
    To investigate the effectiveness of Lipophlavon for the complex
    treatment of the patients with trauma keratitis.
    Methods
    The study included 120 patients (120 eyes) with trauma keratitis. The
    patients were randomly split into two groups similar in age and sex.
    The patients of the study group (80 people, 80 eyes) were given
    Lipophlavon instillations, eye drops manufactured by
    “Biolek” (Kharkov, Ukraine), up to 6-8 times a day as a component of a
    standard treatment. The patients of the control group underwent
    standard treatment only (cyloxan instillations 4 times a day,
    solcoseril-gel). Traditional clinical ophthalmic research methods were
    used.
    Results
    Lipophlavon is well tolerated, it doesn’t produce side effects or
    allergic reactions. Lipophlavon is effective in the treatment of the
    patients with trauma keratitis: fluorescin test shows a 2,1 times
    speedier epitalization, the period of full recovery is 2,0±0,06 days
    shorter, eye pain and subjective complaints persist 2,7±0,03 days
    shorter as compared to the control group.
    Summary/Conclusions
    The results of the clinical trial have made it possible to recommend
    Lipophlavon as an eye medication speeding up regeneration and full
    recovery as well as an effective anti-inflammatory drug in the complex
    treatment of trauma keratitis.

    104. Jahrestagung der Deutschen Ophthalmologischen
    Gesellschaft (DOG). Berlin, 21.-24.09.2006.
    Düsseldorf, Köln: German Doc 06dogFR.17.02
    http://www.egms.de/en/meetings/dog2006/06dog264.shtml
    Published: 18-09-2006

    © 2006 Petrunya et al; licensee .


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    ironjustice, Apr 13, 2009
    #1
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  2. ironjustice

    ironjustice Guest

    liposome
    eye medication Lipophlavon, containing antioxidant, kvertsetin,
    phosphatidilholine lecitin<<

    Identification of the compound in a potent cranberry juice
    extract that inhibits lipid oxidation in comminuted muscle
    Food Chemistry, Volume 115, Issue 3, 1 August 2009, Pages 924-932
    Priya Kathirvel, Yuansheng Gong, Mark P. Richards

    Abstract
    An extract prepared from cranberry juice powder using a mixture
    of chloroform and methanol was particularly effective at inhibiting
    lipid oxidation in mechanically separated turkey (MST), providing
    more than 3 weeks of additional stability during −4 °C storageat
    a usage level of 0.1% (wet weight basis).
    The chloroform extract was fractionated by flash chromatography
    (FC) and analysed using reverse-phased high performance liquid
    chromatography (RP-HPLC) with UV/vis diode array detection to
    identify the component(s) present in the fractions.
    One of the five fractions obtained was effective in delaying the
    formation of lipid peroxides and thiobarbituric acid reactive
    substances (TBARS) in MST, while the remaining fractions had
    little to no inhibitory action.
    Mass spectrometry (MS) analysis indicated the presence of two
    flavonols, quercetin and quercetin-3-O-(6″-benzoyl)-β-galactoside
    in the inhibitory fraction.
    This fraction (containing quercetin at 467 μmol/kg MST) inhibited
    lipid oxidation in MST similarly to pure quercetin added to MST
    at the same concentration.
    This indicated that quercetin accounted for all or nearly all of the
    inhibitory capacity in the chloroform extract.


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    DEAD PEOPLE WALKING
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    ironjustice, Apr 16, 2009
    #2
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