Increased Iron In Eye

Discussion in 'Eye-Care' started by ironjustice, May 5, 2008.

  1. ironjustice

    ironjustice Guest

    (2008) Study of the eye and lacrimal glands in experimental iron
    overload in rats in vivo
    Anatomical Science International 83 (1) , 11–16
    Maria Repanti, Sotiris P. Gartaganis, Nikoleta M. Nikolakopoulou,
    Aikaterini Ellina, Dimitris A. Papanastasiou Abstract
    Original Article
    Study of the eye and lacrimal glands in experimental iron overload in
    rats in vivo
    Maria Repanti 11 Institute of Pathology, St Andreas General Hospital
    of Patras and Departments of , Sotiris P. Gartaganis 22 Ophthalmology
    and , Nikoleta M. Nikolakopoulou 33 Pediatrics, School of Medicine,
    University of Patras, Patras, Greece, Aikaterini Ellina 33 Pediatrics,
    School of Medicine, University of Patras, Patras, Greece and Dimitris
    A. Papanastasiou 33 Pediatrics, School of Medicine, University of
    Patras, Patras, Greece1 Institute of Pathology, St Andreas General
    Hospital of Patras and Departments of 2 Ophthalmology and 3
    Pediatrics, School of Medicine, University of Patras, Patras, Greece
    Correspondence: Dimitris A. Papanastasiou, Department of Pediatrics,
    School of Medicine, University of Patras, 265 00 Patras, Greece.
    Email:
    Key words: eye, hemosiderosis, lacrimal glands, transferrin.
    Abstract

    A variety of syndromes leading to hemosiderosis in men cause ocular
    lesions.
    The purpose of the present study was to determine the distribution of
    iron and of transferrin in the eyes and lacrimal glands of rats in
    experimental hemosiderosis, so as to achieve a better understanding of
    the formation of the ocular lesions observed in patients with advanced
    hemosiderosis.
    In order to achieve hemosiderosis the rats were fed 3% (w/w) carbonyl
    iron or received i.p. or i.v. polymaltose iron.
    Hemosiderin deposits were detected in macrophages lying in the
    interlobular connective tissue of lacrimal glands, in the interstitial
    connective tissue of the choroid, in the ciliary body, in the iris and
    extracellularly in the sclera in all animals that received iron i.v.
    Also, scanty hemosiderin laden macrophages were found to a lesser
    degree in interstitial connective tissue of the choroid and in the
    interlobular connective tissue of lacrimal glands in animals that
    received iron i.p.
    No iron deposits were detected in the eye and lacrimal glands of
    control rats and in rats that were on an iron enriched diet.
    No transferrin was detected in the eye and in the lacrimal glands,
    neither in the control rats nor in the rats that received iron.
    Experimental iron overload leads to increased iron deposition in
    tissues of the eye and lacrimal glands, whereas no transferrin could
    be detected in the aforementioned organs.
    doi:10.1111/j.1447-073X.2007.00195.x
    Anatomical Science International
    Volume 83 Issue 1 Page 11-16, March 2008

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    Tom


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    ironjustice, May 5, 2008
    #1
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  2. ironjustice

    ironjustice Guest

    On May 5, 10:35 am, "" <>
    wrote:hemosiderin in connective tissue <<

    "connective tissue of lacrimal glands,
    connective tissue of the choroid, connective tissue of the choroid ,
    interlobular connective tissue"

    Sooo would connective tissue disease be related ALSO to iron .. ?

    In the leech iron builds in connective tissue ..


    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://tinyurl.com/2r2nkh


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk
     
    ironjustice, May 6, 2008
    #2
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