When the eye receives a shot of Macugen, Avastin, or Lucentis, the\nIOP has a tendency to rise because of the volume of the injected\ndrug. After awhile, the pressure reduces (hopefully) to some nominal\nvalue (i.e., the extra volume leaves). Question, what is the\nmechanism of this volume reduction? The aqueous humor has its own\nsource and drain, and is blocked from the vitreous (wikipedia tells\nme, quote from them) "In health the aqueous humour does not mix with\nthe firm, gel-like vitreous humour because of the lens and its Zonule\nof Zinn between the two."\n\nSo if the shot is into the vitreous, how does that pressure reduce?\nThrough the aqueous humor drain? Somehow?\n\nDon W.