Iron And Eye

Discussion in 'Optometry Archives' started by ironjustice, Nov 4, 2009.

  1. ironjustice

    ironjustice Guest

    This would be PREdisposal to damage.
    Thanks to the dweeeeebs fortifying our food ..
    ----------------

    Neuroprotective Effects of Tempol on Retinal Ganglion
    Cells in a Partial Optic Nerve Crush Rat Model with
    and Without Iron Load.
    Thaler S, Fiedorowicz M, Rejdak R, Choragiewicz TJ,
    Sulejczak D, Zarnowski T, Zrenner E, Grieb P, Schuettauf F.

    Centre for Ophthalmology, University of Tübingen, Tübingen, Germany.

    Iron overload can contribute to oxidative stress in many tissues.
    We studied the effects of pre-treatment with iron dextran on RGC
    loss in a calibrated partial optic nerve crush (PONC) model in rats,
    along with the protection offered by tempol
    (4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxyl, a membrane-
    permeable
    superoxide dismutase mimetic and free-radical scavenger), in the same
    experimental paradigm.
    A total of 40 rats in 6 groups of 5-8 animals each underwent PONC in
    one eye and sham crush in the other.
    Animals were pre-treated with a single iron dextran load 24hours prior
    to
    PONC, and treated with Tempol 6hours before and then once daily after
    PONC.
    Control animals were treated with PBS. RGC were retrogradely labeled
    with a fluorescent marker; all data are expressed in percent of the
    RGC
    count in the respective sham-treated eye.
    Immunohistochemistry was performed to visualize 3-nitrotyrosine, a
    marker of nitroxidative stress.
    PONC without iron pretreatment resulted in the survival of only 31.4%
    of labeled RGC after 7 days.
    Even fewer RGC (12.7%) survived after PONC with iron pretreatment.
    However, tempol in doses of 20mg/kg of body weight (BW) significantly
    attenuated this effect when given as described above; in the group
    without
    iron pretreatment the number of surviving RGC doubled from 31.4% to
    62.1%.
    In the group with iron pretreatment the survival rate of RGC increased
    even
    more pronouncedly, from 12.7% without tempol to 46.2% with tempol.
    Tempol in doses of 1mg/kg BW and 5mg/kg BW showed no significant
    rescue of RGC.
    Immunostaining showed nitrotyrosine-positive RGCs in PONC but not in
    sham-treated eyes and an increase in positive cells after iron load.
    Tempol treatment reduced nitrotyrosine staining in both the iron and
    non-iron
    groups.
    Our results demonstrate that PONC results in significantly greater
    RGC
    damage when iron pretreatment is performed, and that the compound
    tempol
    may provide additional protection for RGC in cases of neuronal damage
    both
    with and without prior iron treatment.

    PMID: 19883642


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    ironjustice, Nov 4, 2009
    #1
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  2. ironjustice

    Ken Guest

    Spamming Canuck Fuckwit
     
    Ken, Nov 4, 2009
    #2
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  3. ironjustice

    ferrous Guest

    "This would be PREdisposal to damage.
    Thanks to the dweeeeebs fortifying our food .."

    Only if the "pretreatment" involved adding an iron sugar mixture to one
    of your crushed eyeballs, after it was crushed.

    We are getting desperate now.
     
    ferrous, Nov 4, 2009
    #3
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