Iron And Macular Degeneration

Discussion in 'Optometry Archives' started by ironjustice, Aug 19, 2009.

  1. ironjustice

    ironjustice Guest

    Iron and age-related macular degeneration.
    Klin Oczna. 2009;111(4-6):174-7.
    Błasiak J, Skłodowska A, Ulińska M, Szaflik JP.
    Department of Molecular Genetics, University of Lodz,
    Lodz, Poland.

    Iron can be involved in the pathogenesis of age-related
    macular degeneration (AMD) through the oxidative stress.
    In siderosis, exogenous iron can cause retinal degeneration
    which can be also associated with elevated retinal iron
    levels resulting in hereditary defects in iron homeostasis.
    Iron is transported into the retina by the endocytosis of iron
    complexed with transferrin and stored in complex with ferritin.
    The retinal pigmented epithelium and the neuroretinal vasculature
    serve as blood-retina barriers and disruption of homeostasis at
    these barriers may result in iron overload.
    There is firm experimental evidence that retinas of AMD patients
    contain more iron than retinas of the healthy subjects, but the
    question whether it is the reason or a consequence of AMD remains
    Excessive iron can cause damage to protein, lipids and DNA through
    the generation of free radicals in the Fenton reaction.
    Therefore, iron may play a role in the pathogenesis of AMD as a
    source of free radical damage but this hypothesis has not been
    verified experimentally and further studies are needed to establish
    the relationship between disturbance in iron homeostasis and AMD.

    PMID: 19673453

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    ironjustice, Aug 19, 2009
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  2. ironjustice

    Neil Brooks Guest

    Ah, yes. The 2nd runner up to Otis Brown in's nut-job
    department rears his ugly head again....
    Neil Brooks, Aug 19, 2009
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