Iron And Macular Degeneration

Discussion in 'Optometry Archives' started by ironjustice, Jun 23, 2010.

  1. ironjustice

    ironjustice Guest

    "Catalyzed by iron"

    Cholesterol oxidation in the retina: Implications of 7-ketocholesterol
    formation in
    chronic inflammation and age-related macular degeneration.
    Rodriguez IR, Larrayoz IM.
    J Lipid Res. 2010 Jun 21.
    National Eye Institute, NIH, United States.

    This review will discuss the formation and potential implications of 7-
    (7KCh) in the retina.
    7KCh is a pro-inflammatory oxysterol known to be present in high
    amounts in oxidized
    low density lipoprotein deposits associated with atheromatous
    7KCh is generated in situ in these lipoprotein deposits where it can
    accumulate and
    reach very high concentrations.
    In normal primate retina 7KCh has been found associated with
    lipoprotein deposits in
    the choriocapillaris, Bruch's membrane and the retinal pigment
    epithelium (RPE).
    In photodamaged rats, 7KCh has been found in the neural retina in
    areas of high
    mitochondrial content, ganglion cells, photoreceptor inner segments
    and synapses
    and the RPE.
    Intermediates found by LCMS indicate 7KCh is formed via a free radical
    mechanism catalyzed by iron.
    7KCh seems to activate several kinase signaling pathways that work via
    and cause the induction of VEGF, IL-6 and IL-8.
    There seems to be little evidence of 7KCh metabolism in the retina
    although some
    form of efflux mechanism may be active.
    The chronic mode of formation and the potent inflammatory properties
    of 7KCh
    indicate it may be an ''age-related'' risk factor in aging diseases
    such as atherosclerosis,
    Alzheimer's and age-related macular degeneration.

    PMID: 20567027
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    ironjustice, Jun 23, 2010
  2. ironjustice

    Ken Guest

    OCD suffering Canuck Dickhead
    Ken, Jun 23, 2010
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