Iron-binding drugs / macular degeneration

Discussion in 'Optometry Archives' started by ironjustice, Oct 28, 2006.

  1. ironjustice

    ironjustice Guest

    Iron induced oxidative damage as a potential factor in age-related
    macular degeneration: the cogan lecture.
    Dunaief JL
    Invest Ophthalmol Vis Sci. 2006 Nov ; 47(11): 4660-4

    Iron is a potent generator of oxidative damage whose levels increase
    with age, potentially exacerbating age-related diseases. Several lines
    of evidence suggest that iron accumulation may be a factor in
    age-related macular degeneration (AMD). AMD retinas have more iron
    within the photoreceptors, RPE, and drusen than do age-matched control
    retinas. Accelerated AMD-like maculopathy develops in patients with
    retinal iron overload from the hereditary disease aceruloplasminemia.
    Mice with retinal iron overload resulting from knockout of
    ceruloplasmin and its homologue hephaestin exhibit retinal degeneration
    with some features of AMD, including subretinal neovascularization,
    accumulation of RPE lipofuscin and sub-RPE deposits, and
    RPE/photoreceptor death. Increased understanding of the mechanisms of
    retinal iron homeostasis may help in the development of therapies to
    prevent iron overload. For example, herein it is shown that one
    regulator of systemic iron homeostasis, HFE, is expressed in the RPE.
    Thus, patients with the common disease hereditary hemochromatosis,
    which is often caused by an HFE mutation, may have retinal iron
    overload predisposing to AMD. Preliminary data suggest that iron
    chelation can reduce RPE iron overload in mice and protect them from
    degeneration, suggesting that iron-binding drugs may one day prove
    useful in reducing RPE oxidative stress and decreasing the risk of AMD
    progression.

    Who loves ya.
    Tom


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    ironjustice, Oct 28, 2006
    #1
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  2. ironjustice

    oxyman Guest

    "Iron induced oxidative damage..."

    Right on, oxygen is bad, it is the cause of all disease, find a disease
    and oxygen is always involved.

    Jesus was a fish eater.
     
    oxyman, Oct 28, 2006
    #2
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