Iron In Eye Disease

Discussion in 'Eye-Care' started by ironjustice, Dec 10, 2008.

  1. ironjustice

    ironjustice Guest

    Iron homeostasis and eye disease.
    Loh A, Hadziahmetovic M, Dunaief JL.
    F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute,
    University of Pennsylvania, 305 Stellar-Chance Labs, 422 Curie
    Boulevard, Philadelphia, PA 19104, USA.

    Iron is necessary for life, but excess iron can be toxic to tissues.
    Iron is thought to damage tissues primarily by generating oxygen free
    radicals through the Fenton reaction. We present an overview of the
    evidence supporting iron's potential contribution to a broad range of
    eye disease using an anatomical approach. Firstly, iron can be
    visualized in the cornea as iron lines in the normal aging cornea as
    well as in diseases like keratoconus and pterygium. In the lens, we
    present the evidence for the role of oxidative damage in
    cataractogenesis. Also, we review the evidence that iron may play a
    role in the pathogenesis of the retinal disease age-related macular
    degeneration. Although currently there is no direct link between
    excess iron and development of optic neuropathies, ferrous iron's
    ability to form highly reactive oxygen species may play a role in
    optic nerve pathology. Lastly, we discuss recent advances in
    prevention and therapeutics for eye disease with antioxidants and iron

    PMID: 19059309

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    ironjustice, Dec 10, 2008
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  2. ironjustice

    serebel Guest

    In general, don't poke anything metallic in your eye. It's not very
    serebel, Dec 11, 2008
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