Iron In Retinal and Macular Degeneration

Discussion in 'Optometry Archives' started by ironjustice, Nov 11, 2008.

  1. ironjustice

    ironjustice Guest

    "Iron as a target in eye degeneration"

    Alteration in Iron Metabolism During Retinal Degeneration in rd10
    Invest Ophthalmol Vis Sci. 2008 Nov 7.
    Deleon E, Lederman M, Berenstein E, Meir T, Chevion M, Chowers I.
    Ophthalmology, Hadassah - Hebrew University Medical Center, Jerusalem,

    Altered iron metabolism was implicated in retinal and macular
    This study was designed to further elucidate iron homeostasis during
    the course of retinal degeneration in mice.
    Retinal mRNA and protein expression of transferrin, transferrin
    receptor, and ceruloplasmin, were evaluated during retinal
    degeneration in rd10 mice and chemokine receptor 2 (ccr2) deficient
    mice. Retinal ferritin protein levels, ferritin-bound iron, and total
    iron were evaluated in rd10 mice.
    Transferrin and ceruloplasmin mRNA levels increased between 2- and 12-
    fold during the course of retinal degeneration in rd10 mice compared
    with same age controls (p<0.01), while transferrin receptor mRNA
    levels increased only at late stages of the degeneration in rd10 mice
    (2.7-fold, p = 0.005).
    Transferrin mRNA also increased in retinas of aged ccr2 deficient mice
    (1.5-fold, p = 0.05).
    Transferrin and ceruloplasmin protein levels corroborated with mRNA
    levels changes in rd10 mice albeit at a lower magnitude. Retinal
    ferritin protein levels increased between 1.5-fold and 2-fold (p<0.03)
    in rd10 mice, and ferritin bound iron levels increased 1.6-fold in 3
    week old rd10 mice (p = 0.03).
    Three weeks old rd10 mice also had 1.4-fold increase in total retinal
    iron levels (p=0.05).
    Combined with previous reports these data suggest that retinal
    degenerations are associated with altered iron homeostasis regardless
    of the primary insult. Given iron's potential for generation of
    oxidative injury, its role as a therapeutic target in retinal and
    macular degenerations should be evaluated.

    PMID: 18997094

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    ironjustice, Nov 11, 2008
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