Iron Overload May Lead To Macular Degeneration

Discussion in 'Optometry Archives' started by ironjustice, Mar 1, 2008.

  1. ironjustice

    ironjustice Guest

    Published as doi: 10.1096/fj.07-8396com.
    (The FASEB Journal. 2007;21:4077-4086.)
    (c) 2007 FASEB This Article
    N-tert-butyl hydroxylamine, a mitochondrial antioxidant, protects
    human retinal pigment epithelial cells from iron overload: relevance
    to macular degeneration
    Ludmila A. Voloboueva, David W. Killilea, Hani Atamna and Bruce N.
    Ames
    Children's Hospital Oakland Research Institute, Nutrition and
    Metabolism Center, Oakland, California, USA

    1Correspondence: Children's Hospital Oakland Research Institute,
    Nutrition and Metabolism Center, 5700 Martin Luther King Jr. Way,
    Oakland, CA 94609-1673, USA. E-mail:

    Age-related macular degeneration (AMD) is the leading cause of severe
    visual impairment in the elderly in developed countries. AMD patients
    have elevated levels of iron within the retinal pigment epithelia
    (RPE), which may lead to oxidative damage to mitochondria, disruption
    of retinal metabolism, and vision impairment or loss. As a possible
    model for iron-induced AMD, we investigated the effects of excess iron
    in cultured human fetal RPE cells on oxidant levels and mitochondrial
    cytochrome c oxidase (complex IV) function and tested for protection
    by N-tert-butyl hydroxylamine (NtBHA), a known mitochondrial
    antioxidant. RPE exposure to ferric ammonium citrate resulted in a
    time- and dose-dependent increase in intracellular iron, which
    increased oxidant production and decreased glutathione (GSH) levels
    and mitochondrial complex IV activity. NtBHA addition to iron-
    overloaded RPE cells led to a reduction of intracellular iron content,
    oxidative stress, and partial restoration of complex IV activity and
    GSH content. NtBHA might be useful in AMD due to its potential to
    reduce oxidative stress, mitochondrial damage, and age-related iron
    accumulation, which may damage normal RPE function and lead to loss of
    vision.--Voloboueva, L. A., Killilea, D. W., Atamna, H., Ames, B. N. N-
    tert-butyl hydroxylamine, a mitochondrial antioxidant, protects human
    retinal pigment epithelial cells from iron overload: relevance to
    macular degeneration.


    Key Words: calcitrol * cognition * depression * nutrition * brain
    development * cytokine theory




    Who loves ya.
    Tom


    Jesus Was A Vegetarian!
    http://jesuswasavegetarian.7h.com


    Man Is A Herbivore!
    http://tinyurl.com/a3cc3


    DEAD PEOPLE WALKING
    http://tinyurl.com/zk9fk
     
    ironjustice, Mar 1, 2008
    #1
    1. Advertisements

Ask a Question

Want to reply to this thread or ask your own question?

You'll need to choose a username for the site, which only take a couple of moments (here). After that, you can post your question and our members will help you out.