RP And Blood Test For Genes Re The Heridity Passing On To Children Probability ?

Discussion in 'Optometry Archives' started by Robert11, Sep 23, 2005.

  1. Robert11

    Robert11 Guest


    Have read the links on RP that were suggested in my previous recent post.

    Would like to ask the following, please, as I haven't been able to come up
    with the answer:

    Is there a genetic blood test that will discern if one has the gene (or
    other factors) to pass along RP to one's kids, or give any other information

    If no genetic blood test is available, how can one evaluate the heredity
    "passing-along" probability ?

    Robert11, Sep 23, 2005
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  2. Robert11

    Dr Judy Guest

    RP is a family of retinal disorders with similar clinical features; there
    are more than a dozen kinds, all are genetic but the inheritance pattern,
    expressivity and penetrance varies considerably and different genes are
    involved with each type.

    If you have RP, you have at least one of the genes for sure, the odds of
    your children inheriting the disorder depend upon which type of RP you have.
    The type and inheritance pattern needs to be determined by an RP genetic
    counsellor, who will collect information from your doctors about your
    disease and information about your relatives and their eye history from you.
    Ask the doctor you diagnosed your RP for referral for genetic counselling.

    Dr Judy
    Dr Judy, Sep 24, 2005
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  3. Robert11

    Dr Judy Guest

    Forgot to mention in previous post:

    I'm not aware of blood tests, but there may be, ask an RP expert. If
    available, it would be useful for your kids to have to see if they have the
    disorder. You know that you have it so testing adds nothing to your care.

    Since your children are already here, you can't prevent passing on the gene
    to them. So the real questions are "do your offspring have the disorder"
    and "are they carriers for the gene which they could pass on to their
    children". The first question can only be answered by your children having
    eye exams. There are special electro diagnostic tests that test the
    electrical functioning of the retina and can predict who has RP before there
    are clinical signs. The test cannot predict how severely the condition will
    affect vision. Some carriers also have abnormal retinal or electro signs.

    If your children currently have normal vision, they may not want to know in
    advance if they will get it in later years. There is currently no way to
    prevent the disorder and some people would rather enjoy life now and not
    worry about future events that cannot be avoided. Ask them if they want to
    be tested.

    The only way to avoid passing on the gene to your grandchildren is for your
    children to not have any children. Depending upon whether your children
    think the RP problem is significant, they will choose to have or not have
    children of their own. You can ask them if they would like to talk to the
    genetic counsellor if the counsellor is able to determine your type of RP
    and the likelihood of inheritance..

    Dr Judy
    Dr Judy, Sep 24, 2005
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