White, stringy eye discharge...

Discussion in 'Eye-Care' started by andypatterson24, Nov 26, 2006.

  1. Hello All

    Quick Rundown: I am 24 years old and have been wearing soft contact
    lenses for 10 years. I am a -11.5 in my left eye and a -9.0 in my
    right. I wear toric lenses. 3-4 weeks ago, my toddler son contracted
    viral conjunctivitis which he gave to me. The immediate symptoms of
    that went away after a few days, but ever since, I have had a white,
    stringy discharge that makes wearing my contact impossible (only
    happening in left eye). I have been to the eye doctor several times in
    the last 2 weeks. I have been prescribed Alcon Tobradex, PredForte,
    Refresh PM ointment, and a Z-pack antibiotic. None of these have
    corrected my problem.

    Does anyone have a suggestion on what I have and/or what I can do to
    resolve the issue? It's taking a real toll on my as I can not focus my
    left eye which causes an imbalance and headaches. Thanks in advance
    for reading this....

    andypatterson24, Nov 26, 2006
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  2. andypatterson24

    Neil Brooks Guest

    I'm not a doctor, BUT ... I'm a patient who has done quite a bit of
    research into the preservatives used in many eyedrops.

    Both drops that you mentioned having used are preserved with
    Benzalkonium Chloride (BAK). BAK is well documented [1] to cause
    damage to the surface of the eye ... very quickly. Odds are very good
    that IF this is what you are experiencing (it surely does fit), it will
    resolve on its own.

    [only one citation here, documenting SHORT-term damage done by BAK to
    the surface of the eye.....]


    Impact of short-term exposure of commercial eyedrops preserved with
    benzalkonium chloride on precorneal mucin.Chung SH, Lee SK, Cristol SM,
    Lee ES, Lee DW, Seo KY, Kim EK.
    Institute of Vision Research, Department of Ophthalmology, Yonsei
    University College of Medicine, Seoul, Korea.

    PURPOSE: The aim of this study is to investigate the short-term effects
    of benzalkonium chloride (BAC), a preservative used in many ophthalmic
    topical solutions, on precorneal mucin in humans. METHODS: Immortalized
    human corneal-limbal epithelial (HCLE) cells were exposed to eyedrops
    containing BAC solutions at 0.0025% and 0.01% concentrations for a
    period of 15 min. Human corneal epithelium was acquired with consent,
    as a byproduct of elective excimer photorefractive keratectomy
    procedures after application of Ocuflox eyedrops (0.3% ofloxacin with
    0.0025% BAC) for 1 week before surgery. The relative expression of the
    MUC1 and MUC16 mucin gene was determined by conventional and real-time
    reverse transcription-polymerase chain reaction (RT-PCR). Monoclonal
    antibodies for MUC1 (HMFG-1) and MUC16 (OC125) were used in western
    blot analysis to detect MUC1 and MUC16. Human corneas exposed to 0.01%
    BAC solutions were examined by transmission electron microscopy.
    RESULTS: The expression of MUC1 and MUC16 gene transcripts was not
    changed after exposure to BAC in HCLE cells and human corneal
    epithelium. However, MUC1 and MUC16 were reduced after exposure to BAC
    in HCLE cells and human corneal epithelium. Transmission electron
    microscopy of the anterior corneal surface revealed fixation of the
    mucous layer after exposure to 0.01% BAC for 5 or 15 min; prolonged
    exposure (60 min) to 0.01% BAC destroys the mucous layer. CONCLUSIONS:
    This study demonstrates that short-term exposure to BAC can alter the
    precorneal mucin.
    Neil Brooks, Nov 27, 2006
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